Neuroinflammation and mental health in the first years of life: impact of different experiences of adversity

Neuroinflammation and mental health in the first years of life: impact of different experiences of adversity

Studies indicate that adversity in the first years of life affects neurobiological functioning as well as physiological responses, such as cardiometabolic and immunological functions related to children’s mental health/well-being, suggesting that it is associated with the development of mental health problems. What remains to be clarified, however, are the molecular pathways that link exposure to adversity with the appearance of emotional and behavioral problems, as well as the causal relationship between these variables.

  • Identify the neuroinflammatory mechanisms potentially involved in the relationship between adversity and mental health of children during their early years.
  • Investigate whether, and how, adversity affects the immune system (i) by promoting epigenetic modifications of specific inflammatory genes and/or (ii) by the dysregulation of inflammatory proteins that probably influence well-being, especially in the early years of childhood.

Andrea Cruz (coord.) | ProChild CoLAB
Isabel Soares (coord.) | UMINHO
Rui Godinho (coord.) | SCML

Adriana Sampaio | UMINHO
Ana Mesquita | UMINHO
Helena Grangeia | ProChild CoLAB
Leonor Bettencourt | ProChild CoLAB
Marlene Sousa | ProChild CoLAB
Paulo Freitas | INL
Stephanie Alves | ProChild CoLAB

Neuroinflammation and mental health in the first years of life: impact of different experiences of adversity
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